| Tetrapeptide-14 Delivery Matrix |
| Granactive AR-1423 is a unique delivery matrix which combines a redness diminishing peptide with the anti-oxidant properties of tea, the calming properties of boswellia serrata and the soothing quality of honey. Granactive AR-1423 contains Tetrapeptide-14, a specific peptide sequence that can be used in cosmetic treatments to alleviate the redness associated with rosacea or mild sun exposure. It acts by down regulating interleukin-6 (IL-6) to prevent inflammation, which in turn reduces MMP-1 damage with the net effect of a bright and even skin appearance. |
| Granactive AR-1423 Full Face Redness Study |
Granactive AR-1423 was evaluated in a leave-on cosmetic treatment at a 5% level on several subjects having redness associated with rosacea. This cosmetic treatment was effective at diminishing the redness by 50% over the course of the 4 week study.
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| Inflammation Due to UV-B Exposure |
UVB causes inflammation by increasing interleukin-6 in keratinocytes. The IL-6 then induces fibroblasts to produce MMP-1 (matrix metalloproteinase-1), an enzyme that breaks-down the extra-cellular matrix leading to photoaging. The following dataset demonstrates the superior ability of tetrapeptide-14 to reduce IL-6 in keratinocytes and rapid reduce MMP-1 in fibroblasts to simultaneously alleviate inflammation and photoaging.
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| Puffy Eye Study |
A 6 week, 4 subjects study demonstrates tetrapeptide-14 dramatic reduction of puffiness under the eye. The photo on the left displays tetrapeptide-14 ability to noticeably reduce puffiness in 2 weeks. A mean value of 42.86% puffiness reduction was observed during the 6 week study.
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